5 fluorouracil mechanism of action ppt

Pyrimidine antagonist: 5-Fluorouracil • In system, 5-fluorouracil is converted in to 5-fluoro-2deoxyuridine monophosphate (5-FdUMP), which inhibits thymidylate synthase (form covalent ternary complex with methyl-THFA and thymidylate synthase irreversible inhibition of TS) and blocks the conversion of deoxyuridilic acid to deoxythymidylic acid. • 5-FU incorporated into RNA, interferes with RNA synthesis and causing cytotoxic effect. • 5-FU produces the anticancer effect in the S phase. 5 fluorouracil mechanism of action ppt arcoxia. By September 14, 2020 Uncategorized. You may report side effects to FDA at 1-800-FDA-1088.Other drugs may interact with birth control pills, including prescription and over-the-counter medicines, Remember, keep this and all other medicines out of the reach of children, never share your medicines. 5-FLUOROURACIL and CAPECITABINE decrease the biosynthesis of pyrimidine nucleotides by inhibiting thymidylate synthase, the enzyme that catalyzes the rate limiting step in DNA synthesis. This results in the thymineless death of rapidly growing cells 5-fluorouracil (5-FU) is widely used in the treatment of cancer. Over the past 20 years, increased understanding of the mechanism of action of 5-FU has led to the development of strategies that increase its anticancer activity. Despite these advances, drug resistance remains a significant limitation to the clinical use of 5-FU

Anticancer drugs 3 antimetabolites - SlideShar

  1. Mechanism of action of 5-FU 5-FU is an analogue of uracil with a fluorine atom at the C-5 position in place of hydrogen (FIG. 1). It rapidly enters the cell using the same facilitated trans-port..
  2. 5-Fluorouracil (5-FU) can activate p53 by more than one mechanism: incorporation of fluorouridine triphosphate (FUTP) into RNA, incorporation of fluorodeoxyuridine triphosphate (FdUTP) into DNA.
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SYNONYM(S): 5 -FU, 5 Fluorouracil, NSC 19893 . COMMON TRADE NAME: ADRUCIL®, EFUDEX® CREAM. CLASSIFICATION: antimetabolite. Special pediatric considerations are noted when applicable, otherwise adult provisions apply. MECHANISM OF ACTION: Fluorouracil is an analog of the pyrimidine uracil and thus acts as a pyrimidine antagonist.1 There are three possibl Hormones • Hormone-dependent tumors have steroid receptors in the malignant cells • Their growth can be inhibited by hormones with opposing actions, by hormone antagonists or by agents that inhibit the endogenous hormone synthesis • Hormones or their analogues that have inhibitory actions on target tissues can be used in treatment Dr Mwatonoka Joyce 3 Mechanism of action. The precise mechanism of action has not been fully determined, but the main mechanism of fluorouracil is thought to be the binding of the deoxyribonucleotide of the drug (FdUMP) and the folate cofactor, N5-10-methylenetetrahydrofolate, to thymidylate synthase (TS) to form a covalently bound ternary complex Welcome to Faria's Trading Limited. Facebook Instagram. NEWSLETTER; CONTACT US; FAQ Fluorouracil (5-FU) is a pyrimidine analogue used as an antineoplastic agent to treat multiple solid tumors including colon, rectal, breast, gastric, pancreatic, ovarian, bladder and liver cancer. Fluorouracil is associated with a low rate of transient serum aminotransferase elevations during therapy and has been implicated in rare cases of clinically apparent acute liver injury

5 fluorouracil mechanism of action ppt arcoxi

An estimated minimum tissue concentration of 10-4 to 10-5 M of fluorouracil was required to inhibit thymidylate synthetase activity in human skin. Possible correlation of this biochemical effect with the clinical action of fluorouracil on actinic keratoses is discussed Mechanisms of action of topical 5-fluorouracil: Review and implications for the treatment of dermatological disorders. Abstract Topical 5-fluorouracil has proved to be a useful therapy since its discovery nearly 50 years ago for the treatment of a range of cancers (e.g. skin, colorectal, breast) and dermatological conditions (e.g. cancerous and. Abstract. This is a review on the mechanism of action of FUra. Three main areas are addressed: metabolism,RNA-directed actions of FUra, and DNA-directed actions of FUra. Key words for bibliographic purposes: metabolism, RNA, rRNA, mRNA, tRNA, DNA primase, DNA, thylidylate synthetase, uracil N -glycosylase, FUra, FUrd, FdUrd, FdUMP, RNA splicing,. The complex mechanism of antimycobacterial action of 5-fluorouracil. A combination of chemical genetic and biochemical assays was applied to investigate the mechanism of action of the anticancer drug 5-fluorouracil (5-FU), against Mycobacterium tuberculosis (Mtb). 5-FU resistance was associated with mutations in upp or pyrR We'll assume you're ok with this, but you can opt-out if you wish. This can allow you to use less of the liquid, which can help to decrease any adverse effects.This method is to use a dermaroller, in a process called microneedling.There are convincing studies that how microneedling helps to drastically increase the effectiveness of minoxidil.As you can see from the graph above, the mean hair.

5-Fluorouracil and cisplatin sequential chemotherapy; mechanism of action and clinical application in advanced, unresectable non-small cell lung cancer. Nakano S(1), Niho Y. Author information: (1)First Department of Internal Medicine, Faculty of Medicine, Kyushu University. PMID: 7606103 [PubMed - indexed for MEDLINE] MeSH Terms. Adul 5-Fluorouracil. Trade Names: Adrucil, Efudex, Fluoroplex ®. Drug Class: Antineoplastic / Antimetabolite. Mechanism of Action: A prodrug that undergoes a complex series of biotransformations to ribosyl and dexoxyribosyl nucleotide metabolites. One of these (FdUMP) forms a covalently bound ternary complex with thymidylate synthase and the.

10. Longley DB, Harkin DP, Johnston PG. 5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer. 2003;3(5):330-338. doi:10.1038/nrc1074. 11. Ceilley RI. Mechanisms of action of topical 5-fluorouracil: review and implications for the treatment of dermatological disorders The mechanism of action of 5-FU and its cellular derivatives have been widely studied, and an inhibition of the dUMP to dTMP or thymidylate conversion enzyme, thymidylate synthase, is considered to be the major route toward cytotoxicity [. 1. 5-fluorouracil: mechanisms of action and clinical strategies bullseyeph.co On the Mechanism of the Lethal Action of 5-Fluorouracil on mammalian and of bacterial cells by 5-fluorouracil, two chief modes of action of this drug at the biochemical level have bee

PPT - Nanocell: Mechanism of action PowerPoint

5FU mechanis

  1. Your source for the latest 5 fluorouracil mechanism articles. Follow 5 fluorouracil mechanism trends, innovations and developments on echemi.com
  2. Your source for diversity of 5 fluorouracil mechanism of action articles. Discover 5 fluorouracil mechanism of action trends, innovations and developments on echemi.com
  3. 5-Fluorouracil Product Number F 6627 Store at Room Temperature Product Description Molecular Formula: C4H3FN2O2 Molecular Weight: 130.1 CAS Number: 51-21-8 Melting Point: 282-283 °C1 λmax: 265 nm Extinction coefficient: EmM = 7.07 (0.1 M HCl) pKa: 8.0 1 Synonym: 5-FU, 2,4-dihydroxy-5-fluoropyrimidine 5-Fluorouracil (5-FU) inhibits the.
  4. Fluorouracil Leucovorin Capecitabine Gemcitabine Hydroxyurea Mercaptopurine Methotrexate Pemetrexed Pentostatin Raltitrexed Thioguanine Trimetrexate Uracil / Tegafur (UFT) Mechanism of action: Interfere with DNA synthesis. They are structural analogs or they inhibit several enzymes. S-phase specifi
  5. 5-Fluorouracil (5-FU) is widely used in the treatment of cancer. Over the past 20 years, increased understanding of the mechanism of action of 5-FU has led to the development of strategies that.

Fluorouracil (5-FU) is a remarkable drug that has been available for 41 years and has become the mainstay of chemotherapy for gastrointestinal cancer.[1-7] It is one of a minority of drugs in clinical medicine for which the qualitative spectrum of toxicity changes dramatically when the drug is used in different doses and schedules (Table 1) Fluorouracil is also called 5FU. It is used to treat many types of cancer. It is best to read this information with our general information about chemotherapy and the type of cancer you have.. Your doctor will talk to you about this treatment and its possible side effects before you agree to have treatment Hypertrophic (HTSs) and keloid scars are common dermatological complaints produced by disruption of the normal wound-healing process. Despite a wide array of therapeutic options available to treat these lesions, HTSs and keloids continue to pose a significant challenge to clinicians in everyday practice. The chemotherapeutic drug 5-fluorouracil (5-FU) is a well-known treatment option reserved. methorexate, 5-fluorouracil, 6-mercaptopurine and 6-thioguanine. 4. Identify the unique pharmacokinetic properties of methotrexate, 5-fluorouracil and 6-mercaptopurine. Describe the mechanism of action of the currently approved signal transduction inhibitors, and explain the success of imatinib vs. gefitinib. Contrast conventional therapy. ADVERTISEMENTS: In this article we will discuss about:- 1. Definition of Prolactin 2. Actions of Prolactin 3. Control of Prolactin Secretion 4. Applied Aspects 5. Deficiency. Definition of Prolactin: Prolactin (PRL) is a 199-amino acid single-chain protein and has considerable structural similarity to human growth hormone and hCS. The Prolactin receptor resembles the GH receptor [

5-fluorouracil: mechanisms of action and clinical strategie

The mechanism of action of the 5-Fluorouracil toxicity is thymidylate synthase (TS) inhibition, which can be nullified by the thymidine and strengthened by the calcium folate (CF) and incorporation of fluorouridine-tri phosphate into the RNA, which also can be nullified by the uridine Adenocarcinomas of the pancreas and biliary tract are highly malignant neoplasms, which are found in the advanced stage. Chemotherapy commonly plays a palliative role in the treatment of pancreatic and biliary tract cancers. 5-Fluorouracil (5-FU) is the most widely studied single agent; the response rate of 5-FU is only 20%. Recently, some reports presented interesting results, in which 5-FU. The Action 5 Report is one of the four BEPS minimum standards. Each of the four BEPS minimum standards is subject to peer review in order to ensure timely and accurate implementation and thus safeguard the level playing field. All members of the Inclusive Framework on BEPS commit to implementing the Action 5 minimum standard, and commit to.


Acta Oncologica 35 ( 1996) DIFFERENT INTRAVENOUS ADMINISTRATION TECHNIQUES FOR 5-FLUOROURACIL 209 Nordic multicenter trial comparing 5-FU and leucovorin (n = 100) versus sequential methotrexate, 5-FU and leu- covorin (n = 98), monitored by the Nordic Gastrointesti- nal Tumor Adjuvant Therapy Group (20) were analysed for response and adverse effects of the treatment protocol (flure oh YOOR a sil) Trade Name: Adrucil ®, Other Names: 5-fluorouracil , 5-FU Fluorouracil is the generic name for the trade name drug Adrucil®. In some cases, health care professionals may use the trade name Adrucil® when referring to the generic drug name fluorouracil Bottom Line. The use of topical 5% fluorouracil is most likely to result in successful elimination of actinic keratoses in a field on the head or face. Treatment is once weekly for four weeks. Mode of Action of Flucytosine. Flucytosine act by competitive inhibition of purine base and pyrimidine bae uptake and also indirectly by intracellular metabolism to 5-fluorouracil. Flucytosine also enters into the fungal cell with the helps of cytosine permease; After entering flucytosine started to metabolized 5-fluorouracil within fungal.

ScienceSlides: drug mechanisms PPT

Flucytosine (5-fluorocytosine; Fig. 2) works as an anti-fungal agent through conversion to 5-fluorouracil within target cells. Fluorouracil becomes incorporated into RNA, causingpremature chaintermination,anditinhibitsDNA synthesis through effects on thymidylate synthase. For this mechanism of action, the target cells must posses Based on its mechanism of action, KEYTRUDA can cause fetal harm when administered to a pregnant woman. Advise women of this potential risk. In females of reproductive potential, verify pregnancy status prior to initiating KEYTRUDA and advise them to use effective contraception during treatment and for 4 months after the last dose A comprehensive Phase II clinical trial comparing seven combinations of single agent 5-FU and 5-FU plus LV at various doses and schedules found no significant differences between the regimens in response rate or survival. 38 However, the response rate for single agent 5-FU (500 mg/m 2 /d, daily x 5, IVB) in this trial was 24%, compared with the.

cancer chemotherapy

5-fluorouracil is a chemotherapeutic drug used worldwide in the treatment of metastatic colorectal cancer, either alone or in combination with irinotecan, a topoisomerase I inhibitor. 5-FU is considered to be purely an S phase-active chemotherapeutic agent, with no activity when cells are in G 0 or G 1 [].It is well-established that treatment of cells with 5-FU causes DNA damage, specifically. The mechanism of action of penicillin. Penicillin acylates the active site of Bacillus stearothermophilus D-alanine carboxypeptidase. Penicillin kills susceptible bacteria by specifically inhibiting the transpeptidase that catalyzes the final step in cell wall biosynthesis, the cross-linking of peptidoglycan Function 5-FU and floxuridine, precursors of FdUMP. The prodrug 5-fluorouracil (5-FU) was the first antimetabolite used as a TS inhibitor. It penetrates the cell through the same facilitated transport mechanism as the uracil, due to the analogy between the two molecules (similar shape and size).The transporter recognizes 5-FU as an endogenous molecule Download as PPT, PDF, TXT or read online from Scribd. pyrimethamine inhibits malarial DHFR • For selective targeting important to understand mechanisms of actions of drugs 3 Mechanism of action of antimicrobials is a cytosine analogue • Converted in fungi & GI flora to 5-fluorouracil (5-FU).

MECHANISMS OF ACTION. 5-FC exerts its antifungal effects by interfering with both DNA and protein synthesis. 5-FC is transported into susceptible fungi by cytosine permease then deaminated to 5-fluorouracil (5-FU) by cytosine deaminase . The absence of cytosine deaminase in mammalian cells allows selective effects on fungal cells A combination of chemical genetic and biochemical assays was applied to investigate the mechanism of action of the anticancer drug 5-fluorouracil (5-FU), against Mycobacterium tuberculosis (Mtb). 5-FU resistance was associated with mutations in upp or pyrR. Upp-catalyzed conversion of 5-FU to FUMP was shown to constitute the first step in the mechanism of action, and resistance conferred by. 200mg Viagra Reddit Shallaki, Actifed Syrup Price Uae Betapace, Gemfibrozil Side Effects Kidney Shuddha Guggulu, 5-fluorouracil Mechanism Of Action Ppt Arcoxia, Pilex Tablet Dosage Cefixime, Holy Basil Rama Benefits Sinequan, Silken Tofu Ice Cream No Churn Metoclopramide, Community-acquired Pneumonia Definition Prinivil, What Is Premarin Used.

5-Fluorouracil: mechanisms of action and clinical

Chemotherapeutic agents, also referred to as antineoplastic agents, are used to directly or indirectly inhibit the uncontrolled growth and proliferation of cancer cells. They are classified according to their mechanism of action and include. alkylating agents. , antimetabolites. , topoisomerase inhibitors. , antibiotics, mitotic inhibitors, and One treatment option is glaucoma drainage surgery (trabeculectomy). Antimetabolites are used during surgery to reduce postoperative scarring during wound healing. Two agents in common use are mitomycin C (MMC) and 5-Fluorouracil (5-FU). To assess the effects of MMC compared to 5-FU as an antimetabolite adjunct in trabeculectomy surgery PPT - Docetaxel (D), cisplatin (C), 5-fluorouracil (F) compared to cisplatin (C), 5-fluorouracil (F) for chemotherapy-na PowerPoint presentation | free to download - id: 427202-YjEzM. The Adobe Flash plugin is needed to view this content. Get the plugin no The Complex Mechanism of Antimycobacterial Action of 5-Fluorouracil. Chem Biol. 2014 Dec 23; Authors: Singh V, Brecik M, Mukherjee R, Evans JC, Svetlíková Z, Blaško J, Surade S, Blackburn J, Warner DF, Mikušová K, Mizrahi V Abstract A combination of chemical genetic and biochemical assays was applied to investigate the mechanism of action of..

Interferon-α (IFNα) potentiates the antitumor activity of 5-fluorouracil (FUra) in colon cancer in vitro, in vivo, and clinically. A likely mechanism for this action is the induction by IFNα of thymidine phosphorylase (TP), the first enzyme in one pathway for the metabolic activation of FUra to fluorodeoxyribonucleotides. To test this hypothesis, an expression vector containing the TP cDNA. Although peritoneal dissemination of gastric cancer is common and often causes deterioration of the patient's condition and quality of life (QOL), these patients are usually excluded from clinical trials. We retrospectively investigated the clinical benefit and toxicity of sequential methotrexate and 5-fluorouracil (MTX/5FU) therapy for patients with peritoneal dissemination

This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs Mechanism and kinetic investigations of 5-fluorouracil tautomeric conversions in the gas phase: DFT and CBS-QB3 methods using multichannel Rice-Ramsperger-Kassel-Marcus steady-state approximation theory

Anticancer drugs 1 introduction and classification

1. Molterni et al. Cyclophosphamide, methotrexate, and fluorouracil with and without doxorubicin in the adjuvant treatment of resectable breast cancer with one to three positive axillary nodes. J Clin Oncol 1991; 9: 1124-1130. 2. HPRA Direct Healthcare Professional Communication. 5-Fluorouracil (i.v.), capecitabine and tegafu The current treatment of essential hypertension is based on the following concepts: (1) a single cause has not been identified. Indeed, essential hypertension appears to be a multifactorial disorder. Specific therapy, therefore, is not possible;1 (2) the homeostatic mechanisms that regulate blood pressure are intact in hypertensive subjects and responsive to physiologic and chemical interventions

Anti-cancers and their mechanism of actio

Favipiravir is a broad-spectrum antiviral that has shown promise in treatment of influenza virus infections, in particular due to the apparent lack of emergence of resistance mutations against the drug in cell culture or animal studies. We demonstrate here that a mutation in a conserved region of the viral RNA polymerase confers resistance to favipiravir in vitro and in cell culture Folate metabolism Leucovorin Mechanism of action 5-Fluorouracil, [6R]-5,10-methylene-tetrahydrofolate 摘要 Folates have been used with cytotoxic agents for decades and today they are used in hundreds of thousands of patients annually 5-Fluorouracil (5-FU) Mechanism of Action Fluorouracil is an analogue of thymine in which the methyl group is replaced by a fluorine atom. It has two active metabolites: 5-FdUMP and 5-FdUTP. 5FdUMP inhibits thymidylate synthetases and prevents the synthesis of thymidine, a major building block of DNA. 5-FdUTP is incorporated into RNA by RNA. The purpose of this work is to review the published studies on the mechanisms of action and resistance of 5-fluorouracil. The review is divided into three main sections: mechanisms of anti-tumor action, studies of the resistance to the drug, and procedures for the identification of new genes involved in resistance with microarray techniques. The details of the induction and reversal of the.

5-FU, a pyrimidine analogue with antimetabolite activity, inhibits fibroblastic proliferation in tissue culture and is believed to reduce postoperative scarring by decreasing fibroblast proliferation.... more. For You News & Perspective Drugs & Diseases CME & Education Academy Video. Answer: Qs number 1: -5 -FU (flourouacil) is an anti cancer agent. It's mechanism of action is based on antimetabolite category and it is a thymidylate synthetase (TS) inhibitor. - It blocks TS enzy view the full answe Request PDF | Chlorination of 5-fluorouracil: Reaction mechanism and ecotoxicity assessment of chlorinated products | What happens to drugs in the chlorinating environment? Degradation products. MECHANISM OF ACTION. Fluorouracil is a nucleoside metabolic inhibitor that interferes with the synthesis of deoxyribonucleic acid (DNA) and to a lesser extent inhibits the formation of ribonucleic acid (RNA); these affect rapidly growing cells and may lead to cell death. Fluorouracil is converted to three main active metabolites: 5-fluoro-2.

Floxuridine (5-Fluorouracil 2'-deoxyriboside) is a pyrimidine analog and known as an oncology antimetabolite. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage by activating the ATM and ATR checkpoint signaling pathways in vitro. Floxuridine is a extreamly potent inhibitor for S. aureus infection and induces cell apoptosis Take action Advocacy priorities State advocacy resources Point to remember: Combination therapy of 5-fluorouracil with calcipotriene is an emerging treatment for actinic keratoses, extramammary Paget disease, and, in all probability, other neoplastic disorders World's Best PowerPoint Templates - CrystalGraphics offers more PowerPoint templates than anyone else in the world, with over 4 million to choose from. Winner of the Standing Ovation Award for Best PowerPoint Templates from Presentations Magazine. They'll give your presentations a professional, memorable appearance - the kind of sophisticated look that today's audiences expect

Targeted therapy in gastrointestinal malignancies

Fluorouracil: Uses, Interactions, Mechanism of Action

FARXIGA mechanism of action: Evidence supports cardiac, renal, and metabolic effects of SGLT2i 1 *Includes feedback effects on other systems. Sodium-glucose cotransporter 2, expressed in the proximal renal tubules, is responsible for the majority of the reabsorption of filtered glucose from the tubular lume Упаковка. Состав. Раствор — фторурацил, едкий натр, вода стерильная. Форма выпуск Which of the following is the mechanism of action of 5-fluorouracil? Select one: competitive inhibitor of ribonucleotide reductase O none of the above suicide substrate for thymidylate synthase competitive inhibitor of dihydrofolate reductase O non-competitive inhibitor of thioredoxin reductase What would be a result of a high (Gln) [a-KG] ratio fluorouracil increases effects of antithrombin III by unspecified interaction mechanism. Use Caution/Monitor. Due to the thrombocytopenic effects of fluorouracil, an additive risk of bleeding may be seen in patients receiving concomitant anticoagulants. argatroban. fluorouracil increases effects of argatroban by unspecified interaction mechanism 5-fluorouracil (5-FU) is a base analogue that mimics both uracil and thymine. The dual resemblance endows it with a twofold mode of metabolic activation and of action. One of several initial activation products, 5′-fluorodeoxyuridine, is also used as a drug itself

flucytosine mechanism of action pp

Yeh KH and Cheng AL (1997) High-dose 5-fluorouracil infusional herapy is associated with hyperammonaemia, lactic acidosis and encephalopathy Brit. J Cancer 75(3): 464-465 Cordier P-Y et al. (2011). 5-FU-induced neurotoxicity in cancer patients with profound DPD deficiency syndrome: A report of two cases EMA recommendations on DPD testing prior to treatment with fluorouracil, capecitabine, tegafur and flucytosine. On 30 April 2020, EMA recommended that patients should be tested for the lack of the enzyme dihydropyrimidine dehydrogenase (DPD) before starting cancer treatment with fluorouracil given by injection or infusion (drip) or with the related medicines, capecitabine and tegafur Mechanism of Action for: •ModernaCOVID-19 Vaccine (mRNA-1273) •Pfizer BioNTechCOVID-19 Vaccine (BNT-162b2) Acknowledgments and Permission The mRNA Vaccine Slide Set is a collaborative effort between the University of Washington Infectious Disease fluorouracil mechanism of action - الصيدلية 2050 Today's Article about Fluorouracil Injection by Sandoz How it works, Uses, Side Effects, Interactions Benefits of using this medication Fluorouracil belongs to the group of cancer-fighting medications known as antineoplastics, and specifically to the group of antineoplastics known as. 5 Current Targeted Therapies Class of Drug Mechanism of Action Examples Cancer Application Hormonal therapy Estrogen blockade Testosterone blockade • Tamoxifen, aromatase inhibitors • Leuprolide, bicalutamide Breast Cancer Prostate Cancer Tyrosine Kinase Inhibitors Small molecule blocks cell signaling pathway • Dabrafenib (BRAF.

The most active cytotoxic agent used to date is 5-fluorouracil (5-FU). However, clinical responses are achieved only in a minority of patients. Based on the current knowledge of the mechanism of action of 5-FU, many attempts have been made to improve the clinical results. These include the use of biochemical modulators and different methods of. Comparison of continuously infused 5-fluorouracil with bolus injection in treatment of patients with colorectal adenocarcinoma Paul Seifert MD , Division of Oncology, Wayne State University School of Medicine, and the Milton A. Darling Memorial Center of the Michigan Cancer Foundation at The Grace Hospital, Detroit, M This molecule inhibits the pursuit of HIV-1 reverse transcriptase - a mechanism which HIV-1 virus uses to replicate - by blocking its action. When the processes of reverse transcriptase are blocked, the HIV-1 mechanism of action is terminated making it harder to replicate itself [2]. Though it doesn't fully work as a curing drug, it. fluorouracil for neurologic toxicity. (5.4) Diarrhea: Fluorouracil can cause severe diarrhea. Withhold fluorouracil for severe diarrhea until resolved. (5.5) Palmar-Plantar Erythrodysesthesia (Hand-Foot Syndrome): Fluorouracil can cause hand-foot syndrome. If severe, discontinue fluorouracil until resolved or decreased to Grade 1, then resume at New Insights into the RNA-Based Mechanism of Action of the Anticancer Drug 5'-Fluorouracil in Eukaryotic Cell